Cover of: DNA Topology | Andrew D. Bates

DNA Topology

  • 216 Pages
  • 2.25 MB
  • 3258 Downloads
  • English
by
Oxford University Press, USA
Biochemistry, DNA, Science, Science/Mathematics, Life Sciences - Genetics & Genomics, Science / Genetics, Structure, physiology, ultrastru
The Physical Object
FormatHardcover
ID Numbers
Open LibraryOL9432775M
ISBN 10019856709X
ISBN 139780198567097

DNA Topology: Fundamentals Sergei M Mirkin,University of Illinois at Chicago, Illinois, USA Topological characteristics of DNA and specifically DNA supercoiling influence all major DNA transactions in living cells.

DNA supercoiling induces the formation of unusual secondary structure by specific DNA repeats which can also affect DNA functioning. This book aims to explain these ideas simply, but rigorously, DNA Topology book allow a wider appreciation of DNA Topology starts with a basic account of DNA structure before going on to cover DNA supercoiling, the definitions and physical meanings of linking number, twist, and writhe, and the free energy associated with supercoiling.

DNA Topology book. Read reviews from world’s largest community for readers. There are further complexities beyond the double helix, including supercoilin /5(5).

A very good book for those who wishto learn in more depth the fascinating issue of the DNA topology. It is more a textbook than a popular science book. Its advantage is that the reader will find everything on the subject: a concise description of related mathematics, results.

this is a very small book, and the semi compactness of informations somewhat ameliorate its lack of volume. Moreover, the mathematics, is sporadic, and not in-depth, as afar as topological math goes. Copious pictures, but again, lacking depth.3/5(1).

Description DNA Topology PDF

The unwinding of the DNA strands by helicases affects the overall topology of the DNA (Figure ). For instance, for every 10 base pairs that are unwound (DT=-1), there will be a compensatory increase in writhing (DW=+1) unless the linking number is changed.

Secondary structure is the set of interactions between bases, i.e., which parts of strands are bound to each other. In DNA double helix, the two strands of DNA are held together by hydrogen nucleotides on one strand base pairs with the nucleotide on the other strand. The secondary structure is responsible for the shape that the nucleic acid assumes.

Buy DNA Topoisomerase Protocols: Volume I: DNA Topology and Enzymes (Methods in Molecular Biology) on FREE SHIPPING on qualified orders. DNA Topology provides a solid basis for understanding the physical properties of DNA and its topology, and how this molecule actively participates in many cellular processes.

This book is certainly aimed at specialists, whom it will not diappoint with its detailed treatment of the core subject matter.3/5(1). DNA Topoisomerase Protocols, I: DNA Topology and Enzymes will be of immense value to the many basic scientists and clinicians who want better to understand and to exploit proficiently the wealth of recent discoveries about chromatin structure and its relation to gene expression, about DNA topoisomerases as the targets of antitumor and.

DNA Topology provides a solid basis for understanding the physical properties of DNA and its topology, and how this molecule actively participates in many cellular processes. This book is certainly aimed at specialists, whom it will not diappoint with its detailed treatment of the core subject matter.

There are further complexities beyond the double helix, including supercoiling, knotting and catenation, that are less widely appreciated and understood but which are critical to its function.

This book explains these topological aspects of DNA structure that is suitable for both students and researchers interested in DNA structure and function. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF. You are here: Home Page > Science & Mathematics > Biological Sciences > Molecular & Cell Biology > DNA Topology.

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$ Paperback. Published: 14 April Pages | 6 halftones, 61 line illus. ISBN: Also Available As. This book explains the concepts of DNA topology and discusses their relevance to biology.\/span>\"@ en\/a> ; \u00A0\u00A0\u00A0\n schema:description\/a> \" DNA structure -- Watson-Crick model -- B-form DNA -- A-form DNA -- Z-form DNA -- Alternative DNA structures -- Cruciforms and Holliday junctions -- H-DNA -- Intrinsic curvature and DNA.

Almost all biological processes involving DNA—such as replication, recombination, and transcription—have effects on, and are affected by, the topological state of the DNA. DNA Topology: In Focus provides clear, concise explanations of these concepts in their biological contexts, making it a valuable text for students of molecular biology Price: $ Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more.

Rolf Menzel, Martin Gellert, in Advances in Pharmacology, F Concluding Remarks on the Effects of DNA Supercoiling on Transcription. The results cited above give some indication of the complex interplay between DNA topology and transcription. One can distinguish between effects seen with RNA polymerase and DNA alone, and those which have been found in more complex systems.

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DNA Topoisomerase Protocols, II: Enzymology and Drugs brings together an unprecedented collection of cutting-edge experimental protocols for investigating the catalytic activities of DNA topoisomerases, as well as their specific interactions with topoisomerase-targeted antitumor and antibacterial drugs.

After introduction of these life-sustaining changes in DNA geometry and topology, and after the process that these changes make possible is finished, the original DNA conformation must be restored. Some enzymes maintain the proper geometry and topology by passing one strand of DNA through another by means of a transient enzyme-bridged break in.

Step 1: From the Cisco DNA Center home page, click Topology. Step 2: In the left tree view menu, select the area, site, building, or floor that you are interested in. Step 3: Use the Toggle button to switch between the Geographical map view and the Layer 2 map view.

The Geographical map view displays the sites. Almost all biological processes involving DNA—such as replication, recombination, and transcription—have effects on, and are affected by, the topological state of the DNA.

DNA Topology: In Focus provides clear, concise explanations of these concepts in their biological contexts, making it a valuable text for students of molecular biology Pages: DNA topology is the tertiary conformations of DNA, such as supercoiling, knotting, and catenation.

Topology of DNA can be disrupted by most metabolic processes: RNA polymerase can cause positive supercoils by over-winding the DNA in front of the enzyme, and can also cause negative supercoils by under-winding the DNA behind the : BRENDA entry. Cutting-edge and comprehensive, DNA Topoisomerases: Methods and Protoc.

ols is intended for specialists and non-specialists with an overview of selected hot topics in the field, and the latest protocols to study DNA topology, topoisomerases functions and inhibition by various compounds.

DNA Topology: Fundamentals - Tufts University Published by Guset User, Description: DNA Topology: Fundamentals Sergei M Mirkin,University of Illinois at Chicago.

DNA in its relaxed state usually assumes the B configuration. • It has the minimum energy and deviation • Any deviation can cause a change in the energy level • In prokaryotes, DNA is always circular and so this circularity leads to a lot of different properties of DNA, it leads to the notion of DNA topology.

20   Book: Microbiology (Boundless) 7: Microbial Genetics Expand/collapse global location Many topoisomerase enzymes sense supercoiling and either generate or dissipate it as they change DNA topology.

In part because chromosomes may be very large, segments in the middle may act as if their ends are anchored. As a result, they may be unable to. Read 8 answers by scientists with 6 recommendations from their colleagues to the question asked by Ankit Srivastava on Supercoilingof DNA 1.

Topology A. Right handed supercoiling= negative supercoiling (underwinding) B. Left handed supercoiling= positive supercoiling C. Relaxed state is with no bends D. DNA must be constrained: plasmid DNA or by proteins E. Unraveling the DNA at. DNA supercoiling is a special property of circular, double-stranded DNA that is topological in origin.

It confers new structural and energetic properties. When the ends of a linear DNA molecule are ligated to produce a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken.DNA topology is the study of geometrical and topological properties of circular DNA.

Es-sentially all reactions involving DNA are influenced by its topology. [4] is a good reference book for general DNA topology. Some knot theory books include expository chapters on theFile Size: 97KB.title = "DNA nanotechnology and topology", author = "Nadrian Seeman and H.

Wang and Jing Qi and Xiaojun Li and Xiaoping Yang and Yinli Wang and Hangxia Qiu and B. Liu and Zhiyong Shen and Weiqiong Sun and Furong Liu and Molenda, {John J.} and Du, {Shou Ming} and Junghuei Chen and Mueller, {John E.} and Yuwen Zhang and Fu, {Tsu Ju} and Siwei Zhang",Cited by: 1.